Transine co-founder, Professor Piero Carninci’s lab recently contributed new seminal understandings to the SINEUP® field. The team described how two cellular proteins, PTBP1 and HNRNPK, are critical to drive the co-localisation of SINEUPs® with their target mRNA as well as the assembly of the translational initiation complex. The results provide important keys to understand the mechanism driving SINEUP® efficiency and their translation boosting properties.
The results were described in N. Toki et al., ‘SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies’. The publication received important coverage, including being highlighted as Editor’s choice in The Scientist.
The publication appeared only a few weeks after another important finding was described on the role of chemical modification in boosting synthetic SINEUPs® efficiency in ‘Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation’.